Modulation of a Glycoprotein Recognition

Dr. Summerfield's present address is Department of Medicine, Royal Free Hospital, London, England. Address reprint requests to Dr. Jones. Received for publication 13 July 1981 and in revised form 15 February 1982. population of these cells. In addition, in vivo studies of the fate of intravenously administered '251-agalactoorosomucoid indicated that its rate of disappearance from plasma, hepatic accumulation, and catabolism were slower in diabetic than in normal rats. The results suggest that modulation of a carbohydrate-mediated glycoprotein recognition system located on hepatic endothelial cells can be induced by glucose and glucose-conjugated proteins and by fasting and diabetes mellitus. The findings in this study suggest a mechanism for abnormal glycoprotein metabolism in diabetes mellitus.